نتایج جستجو برای: low-energy electrons multicellular model Geant4-DNA
تعداد نتایج: 4003989 فیلتر نتایج به سال:
Today, targeted radiation therapy (TRT) methods for cancer treatment, besides the goal of completely destroying the target tumor, attempts to prevent nearby healthy cells from exposure to ionizing radiation as far as possible. Hence, short-range charged particles, such as low-energy electrons that are suited to achieving these two goals together, play an important role in TRT and so, adoption o...
Introduction: The goal of any type of radiation therapy in the treatment of tumors, in addition to destroying cancer cells, is to minimizing radiation to nearby healthy cells and thus reducing side damages. For this purpose, targeted radiation therapy (TRT) is more effective in treating of single cells or small cluster of cells. The main factor in the success of this method is...
Typically water is used as an analog material for Deoxyribonucleic Acid (DNA) in Monte Carlo simulations of biological radiation interactions. Prior to this work, it was unclear whether water is an appropriate stand-in for DNA when simulating direct radiation damage on the nano scale. The increased interest in targeted tumor therapy using Auger electrons has requires an understand of the radiob...
Determination of the relative biological effectiveness (RBE) of Auger electrons is a challenging task in radiobiology. In this study, we have estimated the RBE of internal conversion (IC) and Auger electrons released during Gadolinium neutron capture reaction (GNCR) by means of biological weighting functions (BWFs) with microdosimetric approach. Regarding the different distribution of Gadoliniu...
This paper presents the first study that uses the GEometry ANd Tracking 4 (GEANT4) toolkit to do quantitative comparisons with other modeling results related to the production of terrestrial gamma ray flashes and high-energy particle emission from thunderstorms. We will study the relativistic runaway electron avalanche (RREA) and the relativistic feedback process, as well as the production of b...
Introduction: Now day Ionizing radiation has found increasing applications in cancer treatment. However, in the treatment different kinds and size of tumors especially metastatic and small size tumors, conventional methods of external radiation therapy are not common. In radionuclide therapy, the use of monoclonal antibodies has made it possible to achieve maximum dose to small size tumor and m...
The algorithm for the simulation of energy losses of low energy ions is described. The details of its implementation in GEANT4 are discussed. The comparison of the simulation results with the experimental data is presented. 1 Introduction GEANT4[1] is a toolkit for Monte Carlo particle transport simulation for a wide range of applications, based on the Object Oriented technology. The GEANT4 mod...
We present a multi-scale simulation of the early stage of DNA damages by the indirect action of hydroxyl ((•)OH) free radicals generated by electrons and protons. The computational method comprises of interfacing the Geant4-DNA Monte Carlo with ReaxFF molecular dynamics software. A clustering method was employed to map the coordinates of (•)OH-radicals extracted from the ionization-track-struct...
The contribution of low-energy particles down to ~200 eV the dose deposited on very near surface materials subject space environment is investigated by means GEANT4 Monte Carlo simulations. dose, parts Global Radiation Earth ENvironment (GREEN) spectra (200 eV-40 keV for electrons, 200 eV-100 protons), compared with calculations performed AE8/AP8. Both geostationary earth orbit (GEO) and low (L...
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